Clinical Decision Support Tool and Rapid Point-of-Care Platform for Determining Disease Severity in Patients with COVID-19

Michael P McRae; Glennon W Simmons; Nicolaos J Christodoulides; Zhibing Lu; Stella K Kang; David Fenyo; Timothy Alcorn; Isaac P Dapkins; Iman Sharif; Deniz Vurmaz; Sayli S Modak; Kritika Srinivasan; Shruti Warhadpande; Ravi Shrivastav; John T McDevitt

Previously we have used the p-BNC platform to develop various wellness and disease severity scores for oral cancer 18, 19, 32 and cardiac heart disease. 22 Shown in Figure 5 Finally, we evaluated the COVID-19 Severity Score on data from a case study of 12 hospitalized COVID-19 patients. 28 Figure 6 presents a scatter/box plot of COVID-19 Severity Scores on three groups of patients. COVID-19 Severity Scores were found to increase with disease severity. Moderate (patients whose only complication was pneumonia), Severe (patients with both pneumonia and ARDS), and Critical (patients with one or more of severe ARDS, respiratory failure, cardiac failure, or shock) groups had median (IQR) COVID-19 Severity Scores of 9 (4-17), 28 (24) (25) (26) (27) (28) (29) (30) (31) (32) (33) (34) (35) (36) , and 36 (28-83), respectively. Although this analysis evaluates a small sample of patients, these preliminary results show potential for the COVID-19 Severity Score to be calibrated to a disease severity scale. In addition to cross-sectional and population-based comparisons, this COVID-19 Severity Score could also be used for longitudinal monitoring of patients. In this manner, an individual's time series measurements could be used to track changes . CC-BY-NC-ND 4.0 International license It is made available under a author/funder, who has granted medRxiv a license to display the preprint in perpetuity.