Author: Wang, Shuang; Peng, Yun; Wang, Rongjuan; Jiao, Shasha; Wang, Min; Huang, Weijin; Shan, Chao; Jiang, Wen; Li, Zepeng; Gu, Chunying; Chen, Ben; Hu, Xue; Yao, Yanfeng; Min, Juan; Zhang, Huajun; Chen, Ying; Gao, Ge; Tang, Peipei; Li, Gang; Wang, An; Wang, Lan; Zhang, Jinchao; Chen, Shuo; Gui, Xun; Yuan, Zhiming; Liu, Datao
Title: Characterization of neutralizing antibody with prophylactic and therapeutic efficacy against SARS-CoV-2 in rhesus monkeys Cord-id: 1jg51jz0 Document date: 2020_11_13
ID: 1jg51jz0
Snippet: Efficacious interventions are urgently needed for the treatment of COVID-19. Here, we report a monoclonal antibody (mAb), MW05, with SARS-CoV-2 neutralizing activity by disrupting the interaction of receptor binding domain (RBD) with angiotensin-converting enzyme 2 (ACE2) receptor. Crosslinking of Fc with FcγRIIB mediates antibody-dependent enhancement (ADE) activity by MW05. This activity is eliminated by introducing the LALA mutation to the Fc region (MW05/LALA). Potent prophylactic and thera
Document: Efficacious interventions are urgently needed for the treatment of COVID-19. Here, we report a monoclonal antibody (mAb), MW05, with SARS-CoV-2 neutralizing activity by disrupting the interaction of receptor binding domain (RBD) with angiotensin-converting enzyme 2 (ACE2) receptor. Crosslinking of Fc with FcγRIIB mediates antibody-dependent enhancement (ADE) activity by MW05. This activity is eliminated by introducing the LALA mutation to the Fc region (MW05/LALA). Potent prophylactic and therapeutic effects against SARS-CoV-2 are observed in rhesus monkeys. A single dose of MW05/LALA blocks infection of SARS-CoV-2 in prophylactic treatment and clears SARS-CoV-2 in three days in a therapeutic treatment setting. These results pave the way for the development of MW05/LALA as an antiviral strategy for COVID-19.
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