Sexual Dimorphism in Hemispheric Processing of Faces in Humans: A Meta-Analysis of 817 Cases.

Proverbio, Alice Mado

A well-established neuroimaging literature predicts a right-sided asymmetry in the activation of face-devoted areas such as the fusiform gyrus (FG) and its resulting M/N170 response during face processing. However, the face-related response sometimes appears to be bihemispheric. A few studies have argued that bilaterality depended on the sex composition of the sample. To shed light on this matter, two meta-analyses were conducted starting from a large initial database of 250 ERP/MEG peer-reviewed scientific articles. Paper coverage was 1985-2020. Thirty-four articles met the inclusion criteria of a sufficiently large and balanced sample size with strictly right-handed and healthy participants aged 18-35 and N170 measurements in response to neutral front view faces at left and right occipito/temporal sites. The data of 817 male (n = 414) and female (n = 403) healthy adults were subjected to repeated measures analyses of variance. The results of statistical analyses from the data of 17 independent studies (from Asia, Europe and America) seem to robustly indicate the presence of a sex difference in the way the two cerebral hemispheres process facial information in humans, with a marked right-sided asymmetry of the bioelectrical activity in males and a bilateral or left-sided activity in females.