Author: Farhadian, Shelli; Glick, Laura R.; Vogels, Chantal B.F.; Thomas, Jared; Chiarella, Jennifer; Casanovas-Massana, Arnau; Zhou, Jing; Odio, Camila; Vijayakumar, Pavithra; Geng, Bertie; Fournier, John; Bermejo, Santos; Fauver, Joseph R.; Alpert, Tara; Wyllie, Anne L.; Turcotte, Cynthia; Steinle, Matthew; Paczkowski, Patrick; Cruz, Charles Dela; Wilen, Craig; Ko, Albert I.; MacKay, Sean; Grubaugh, Nathan D.; Spudich, Serena; Aoun Barakat, Lydia
Title: Acute encephalopathy with elevated CSF inflammatory markers as the initial presentation of COVID-19. Cord-id: 6gv6vy4v Document date: 2020_5_12
ID: 6gv6vy4v
Snippet: BACKGROUND: COVID-19 is caused by the severe acute respiratory syndrome virus SARS-CoV-2. It is widely recognized as a respiratory pathogen, but neurologic complications can be the presenting manifestation in a subset of infected patients. CASE PRESENTATION: We describe a 78-year old immunocompromised woman who presented with altered mental status after witnessed seizure-like activity at home. She was found to have SARS-CoV-2 infection and associated neuroinflammation. In this case, we undertake
Document: BACKGROUND: COVID-19 is caused by the severe acute respiratory syndrome virus SARS-CoV-2. It is widely recognized as a respiratory pathogen, but neurologic complications can be the presenting manifestation in a subset of infected patients. CASE PRESENTATION: We describe a 78-year old immunocompromised woman who presented with altered mental status after witnessed seizure-like activity at home. She was found to have SARS-CoV-2 infection and associated neuroinflammation. In this case, we undertake the first detailed analysis of cerebrospinal fluid (CSF) cytokines during COVID-19 infection and find a unique pattern of inflammation in CSF, but no evidence of viral neuroinvasion. CONCLUSION: Our findings suggest that neurologic symptoms such as encephalopathy and seizures may be the initial presentation of COVID-19. Central nervous system inflammation may associate with neurologic manifestations of disease.
Search related documents:
Co phrase search for related documents- academic center and acute encephalopathy: 1, 2
- academic medical center and acute ards respiratory distress syndrome: 1, 2, 3, 4, 5
- academic medical center and acute respiratory sars syndrome virus: 1
- academic medical center and admission prior: 1, 2, 3, 4, 5
- academic medical center and lymphocyte count: 1, 2, 3
- acute ards respiratory distress syndrome and additional day: 1, 2, 3
- acute ards respiratory distress syndrome and adenovirus testing: 1
- acute ards respiratory distress syndrome and admission prior: 1, 2, 3, 4, 5, 6
- acute ards respiratory distress syndrome and lumbar puncture: 1, 2
- acute ards respiratory distress syndrome and lung bronchoalveolar immune cell: 1
- acute ards respiratory distress syndrome and lymphocyte count: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37
- acute ards respiratory distress syndrome and macrophage induced: 1, 2, 3, 4, 5, 6
- acute encephalopathy and lumbar puncture: 1, 2, 3, 4
- acute respiratory sars syndrome virus and additional day: 1
- acute respiratory sars syndrome virus and admission prior: 1, 2
- acute respiratory sars syndrome virus and lymphocyte count: 1, 2, 3, 4, 5, 6, 7
- admission prior and lumbar puncture: 1, 2
- admission prior and lymphocyte count: 1, 2
- lumbar puncture and lymphocyte count: 1
Co phrase search for related documents, hyperlinks ordered by date