A Mini Review on Current Clinical and Research Findings for Children Suffering from COVID-19

Xiao Li; Kun Qian; Ling-ling Xie; Xiu-juan Li; Min Cheng; Li Jiang; Bjoern W. Schuller

Coronaviruses (CoV) are members of the subfamily Coronavirinae in the Coronaviridae family, Nidovirales order. CoV consists of four genera: α, β, γ, and δ coronaviruses. The alpha-and beta-coronaviruses infect only mammals, while the gamma-and delta-coronaviruses mainly infect birds. COVID-19 belongs to the β genus coronaviruses [1] . SARS-CoV-2 is a novel human coronavirus (HCoVs) besides four HCoVs ((α-coronaviruses (229E and NL63), β-coronaviruses (OC43 and HKU1)), Middle East respiratory syndrome coronavirus (MERSr-CoV), as well as the severe acute respiratory syndrome-related coronavirus (SARS-CoV) [1] . It is an enveloped positive single-stranded RNA virus with 60-140 nm in diameter. The shape of SARS-CoV-2 is spherical or elliptical [4, 5] . The consistency of whole genome sequence of SARS-CoV-2 with SARS-like coronavirus in bats (bat-SL-CoVZC45) ranges from 86.9% [5] to 89% [6] . "The SARS-CoV-2 is sensitive to ultraviolet light and heat, and it can be inactivated at 56℃ for 30 minutes. Lipid solvents, except chlorahexidine, such as ethyl ether, and 75 % ethanol can also effectively inactivate the virus" [2, 4] .