Author: Stelzig, Kimberly E.; Canepa-Escaro, Fabrizio; Schiliro, Marta; Berdnikovs, Sergejs; Prakash, Y. S.; Chiarella, Sergio E.
Title: Estrogen regulates the expression of SARS-CoV-2 receptor ACE2 in differentiated airway epithelial cells Cord-id: 2mpst5x8 Document date: 2020_6_1
ID: 2mpst5x8
Snippet: There is marked sexual dimorphism in the current coronavirus disease 2019 (COVID-19) pandemic. Here we report that estrogen can regulate the expression of angiotensin-converting enzyme 2 (ACE2), a key component for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cell entry, in differentiated airway epithelial cells. Further studies are required to elucidate the mechanisms by which sex steroids regulate SARS-CoV-2 infectivity.
Document: There is marked sexual dimorphism in the current coronavirus disease 2019 (COVID-19) pandemic. Here we report that estrogen can regulate the expression of angiotensin-converting enzyme 2 (ACE2), a key component for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cell entry, in differentiated airway epithelial cells. Further studies are required to elucidate the mechanisms by which sex steroids regulate SARS-CoV-2 infectivity.
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