Selected article for: "receptor binding and surface protein"

Author: Sigrist, Christian JA; Bridge, Alan; Le Mercier, Philippe
Title: A potential role for integrins in host cell entry by SARS-CoV-2
  • Cord-id: 2hgwa6pq
  • Document date: 2020_3_1
  • ID: 2hgwa6pq
    Snippet: • Integrin may act as an alternative receptor for SARS-CoV-2 and could be implicated in its transmission and pathology. • The spike protein of SARS-CoV-2 acquired a RGD motif known to bind integrins. This motif is absent from other coronaviruses. • The integrin-binding motif is present at the surface of the spike protein, close to the ACE2 receptor-binding region. • Integrin binding may be a promising therapeutics target, and should be tested experimentally.
    Document: • Integrin may act as an alternative receptor for SARS-CoV-2 and could be implicated in its transmission and pathology. • The spike protein of SARS-CoV-2 acquired a RGD motif known to bind integrins. This motif is absent from other coronaviruses. • The integrin-binding motif is present at the surface of the spike protein, close to the ACE2 receptor-binding region. • Integrin binding may be a promising therapeutics target, and should be tested experimentally.

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