Selected article for: "adaptive innate and antigen presentation"
Author: Kopitar-Jerala, Nataša
Title: The Role of Cysteine Proteinases and their Inhibitors in the Host-Pathogen Cross Talk
  • Cord-id: 2i2v5ecg
  • Document date: 2012_12_25
    • ID: 2i2v5ecg
    Snippet: Proteinases and their inhibitors play essential functional roles in basic biological processes in both hosts and pathogens. Endo/lysosomal cathepsins participate in immune response in pathogen recognition and elimination. They are essential for both antigen processing and presentation (host adaptive immune response) and activation of endosomal Toll like receptors (innate immune response). Pathogens can produce proteases and also natural inhibitors to subvert the host immune response. Several pat
    Document: Proteinases and their inhibitors play essential functional roles in basic biological processes in both hosts and pathogens. Endo/lysosomal cathepsins participate in immune response in pathogen recognition and elimination. They are essential for both antigen processing and presentation (host adaptive immune response) and activation of endosomal Toll like receptors (innate immune response). Pathogens can produce proteases and also natural inhibitors to subvert the host immune response. Several pathogens are sensed through the intracellular pathogen recognition receptors, but only some of them use the host proteolytic system to escape into the cytosol. In this review, I provide an update on the most recent developments regarding the role of proteinases and their inhibitors in the initiation and regulation of immune responses.

    Search related documents:
    Co phrase search for related documents
    • acidic environment and acute respiratory syndrome: 1, 2, 3, 4, 5, 6, 7
    • action mode and acute respiratory syndrome: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • action mode and adaptive immune system: 1, 2
    • action mode and adaptive innate: 1, 2, 3, 4, 5, 6, 7
    • action mode specific and adaptive innate: 1
    • activate pdcs and adaptive immune response: 1
    • activate state and adaptive innate: 1
    • activation follow and acute respiratory syndrome: 1, 2
    • activation marker and acute respiratory syndrome: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15
    • activation marker and adaptive immune response: 1
    • activation marker and adaptive innate: 1, 2
    • activation signal and acute respiratory syndrome: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
    • activation signal and adaptive immune response: 1, 2, 3
    • activation signal and adaptive immune response innate: 1, 2, 3
    • activation signal and adaptive immune system: 1
    • activation signal and adaptive innate: 1, 2, 3, 4, 5
    • activation signal and adaptive innate immune response: 1, 2, 3
    • activation signal trigger and adaptive innate: 1
    • acute respiratory syndrome and adaptive immune response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25