Author: Huang, Wei; Berube, Julie; McNamara, Michelle; Saksena, Suraj; Hartman, Marsha; Arshad, Tariq; Bornheimer, Scott J.; O'Gorman, Maurice
Title: Lymphocyte Subset Counts in COVIDâ€19 Patients: A Metaâ€Analysis Cord-id: 12ienbdx Document date: 2020_6_15
ID: 12ienbdx
Snippet: A reduced peripheral blood absolute lymphocyte count with an elevated neutrophil count has been a consistent observation in hospitalized COVIDâ€19 patients. In this brief metaâ€analysis, the reduction of lymphocyte subset counts in COVIDâ€19 patients was investigated across 20 peerâ€reviewed studies meeting criteria for reporting lymphocyte subset counts and COVIDâ€19 disease severity. CD4+ T cell, CD8+ T cell, B cell, NK cell and total lymphocyte cell counts all showed statistically signif
Document: A reduced peripheral blood absolute lymphocyte count with an elevated neutrophil count has been a consistent observation in hospitalized COVIDâ€19 patients. In this brief metaâ€analysis, the reduction of lymphocyte subset counts in COVIDâ€19 patients was investigated across 20 peerâ€reviewed studies meeting criteria for reporting lymphocyte subset counts and COVIDâ€19 disease severity. CD4+ T cell, CD8+ T cell, B cell, NK cell and total lymphocyte cell counts all showed statistically significant reduction in patients with severe/critical COVIDâ€19 disease compared to mild/moderate disease. T cell subsets showed the largest standardized magnitude of change. In some studies, multivariate analysis has shown that CD4 and/or CD8 T cells counts are independently predictive of patient outcomes.
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