Author: mokhtar, k. m.
Title: Improved RT-PCR SARS-Cov2 results interpretation by indirect determination of cut-off cycle threshold value. Cord-id: 2h0vo6dt Document date: 2020_11_23
ID: 2h0vo6dt
Snippet: ABSTRACT Clinical laboratories of the developing world are overwhelmed with RT PCR SARS Cov2 testing demands. It is of paramount importance that each clinical laboratory use an appropriate cutoff value in the interpretation of SARS Cov2 realtime RT PCR results, which is specific to their laboratory performances as ISO 15189 recommendations stipulate. We applied an indirect statistical method to a large mixed data set of Ct values (ORF1ab and N) to estimate cut-off Ct value (~32 cycles).we conclu
Document: ABSTRACT Clinical laboratories of the developing world are overwhelmed with RT PCR SARS Cov2 testing demands. It is of paramount importance that each clinical laboratory use an appropriate cutoff value in the interpretation of SARS Cov2 realtime RT PCR results, which is specific to their laboratory performances as ISO 15189 recommendations stipulate. We applied an indirect statistical method to a large mixed data set of Ct values (ORF1ab and N) to estimate cut-off Ct value (~32 cycles).we conclude that the use of indirect statistical approaches to estimate cut-off value in the interpretation of SARS-Cov2 real-time RT PCR results may improve differential diagnosis of COVID 19 cases with low risk of infectivity, and may help to better estimates of the burden of COVID 19 disease.
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