Author: Desye Gebrie; Desalegn Getnet; Tsegahun Manyazewal
Title: Efficacy of remdesivir versus placebo for the treatment of COVID-19: A protocol for systematic review and meta-analysis of randomized controlled trials Document date: 2020_4_14
ID: aosmo568_49
Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.09.20059196 doi: medRxiv preprint between study is acceptable, a fixed-effect model will be used to pool the data. On the other hand, if unacceptable heterogeneity detected or if the number of studies are small, a randomeffect model will be used to pool the data [30] . Subgroup analysis will be carried out to identify possible reasons tha.....
Document: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.09.20059196 doi: medRxiv preprint between study is acceptable, a fixed-effect model will be used to pool the data. On the other hand, if unacceptable heterogeneity detected or if the number of studies are small, a randomeffect model will be used to pool the data [30] . Subgroup analysis will be carried out to identify possible reasons that may cause significant heterogeneity between studies. If we get acceptable heterogeneity after the subgroup analysis, we will perform meta-analysis. Otherwise, we will do a narrative description. Sensitivity analysis will be conducted to see the robustness of pooled data by removing low quality studies. Statistical analysis with a p-value < 0.05 will be considered statistically significant.
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