Author: Amrita Banerjee; Dipannita Santra; Smarajit Maiti
Title: Energetics based epitope screening in SARS CoV-2 (COVID 19) spike glycoprotein by Immuno-informatic analysis aiming to a suitable vaccine development Document date: 2020_4_5
ID: iy4knx7j_19
Snippet: The Major Histocompatibility Complex (MHC) binding efficiency of predicted epitops was performed using Immune Epitope Database (IEDB) and Analysis Resource [29] . A total of 5 DPA, 6 DQA and 662 DRB alleles from MHC class II were screened for the detection of best interactive alleles on the basis of highest consensus percentile rank and lowest IC50 value. All the analyses were performed on Human Class II allele, using frequently occurring alleles.....
Document: The Major Histocompatibility Complex (MHC) binding efficiency of predicted epitops was performed using Immune Epitope Database (IEDB) and Analysis Resource [29] . A total of 5 DPA, 6 DQA and 662 DRB alleles from MHC class II were screened for the detection of best interactive alleles on the basis of highest consensus percentile rank and lowest IC50 value. All the analyses were performed on Human Class II allele, using frequently occurring alleles (frequency > 1%), peptide length of 9mers was selected; consensus percentile rank ≤ 1 was used for the selection of peptides.
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