Selected article for: "major cause and mortality morbidity major cause"
Author: Hsieh, I-Ni; Hartshorn, Kevan L.
Title: The Role of Antimicrobial Peptides in Influenza Virus Infection and Their Potential as Antiviral and Immunomodulatory Therapy
  • Cord-id: 3f60q9wc
  • Document date: 2016_9_6
    • ID: 3f60q9wc
    Snippet: Influenza A virus (IAV) remains a major threat that can cause severe morbidity and mortality due to rapid genomic variation. Resistance of IAVs to current anti-IAV drugs has been emerging, and antimicrobial peptides (AMPs) have been considered to be potential candidates for novel treatment against IAV infection. AMPs are endogenous proteins playing important roles in host defense through direct antimicrobial and antiviral activities and through immunomodulatory effects. In this review, we will d
    Document: Influenza A virus (IAV) remains a major threat that can cause severe morbidity and mortality due to rapid genomic variation. Resistance of IAVs to current anti-IAV drugs has been emerging, and antimicrobial peptides (AMPs) have been considered to be potential candidates for novel treatment against IAV infection. AMPs are endogenous proteins playing important roles in host defense through direct antimicrobial and antiviral activities and through immunomodulatory effects. In this review, we will discuss the anti-IAV and immunomodulatory effects of classical AMPs (defensins and cathelicidins), and proteins more recently discovered to have AMP-like activity (histones and Alzheimer’s associated β-amyloid). We will discuss the interactions between AMPs and other host defense proteins. Major emphasis will be placed on novel synthetic AMPs derived from modification of natural proteins, and on potential methods of increasing expression of endogenous AMPs, since these approaches may lead to novel antiviral therapeutics.

    Search related documents:
    Co phrase search for related documents
    • activation recruitment and adaptive immune response: 1, 2, 3, 4
    • activation recruitment and lung host defense: 1
    • activation recruitment and lung inflammation: 1, 2, 3, 4, 5
    • activation recruitment and lung inflammatory: 1, 2, 3, 4, 5
    • activation recruitment and lung injury: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13
    • activation recruitment and lung injury reduce: 1
    • activation recruitment and lung therapy: 1
    • activation recruitment and macrophage monocyte: 1, 2, 3
    • activation recruitment and macrophage response: 1
    • activity test and lung inflammation: 1
    • activity test and lung injury: 1, 2