Selected article for: "conformational change and different sequence"
Author: Amrita Banerjee; Dipannita Santra; Smarajit Maiti
Title: Energetics based epitope screening in SARS CoV-2 (COVID 19) spike glycoprotein by Immuno-informatic analysis aiming to a suitable vaccine development
  • Document date: 2020_4_5
    • ID: iy4knx7j_31
    Snippet: The epitope designing was conducted only with the COVID 19 spike glycoprotein sequence and structure. From the sequence analysis, 10 different locations were found which also showed similarity with SARS CoV and SARS COVID 2 spike glycoprotein in protein BLAST (Figure 4) . Also the motif positions within the spike glycoprotein monomer were represented in figure 4 . Epitopes 1, 4 and 5 were not represented in COVID 19 spike glycoproteins, as they w.....
    Document: The epitope designing was conducted only with the COVID 19 spike glycoprotein sequence and structure. From the sequence analysis, 10 different locations were found which also showed similarity with SARS CoV and SARS COVID 2 spike glycoprotein in protein BLAST (Figure 4) . Also the motif positions within the spike glycoprotein monomer were represented in figure 4 . Epitopes 1, 4 and 5 were not represented in COVID 19 spike glycoproteins, as they were found to be embedded within the virus envelop. Among the others, motifs 2, 3, 6 and 7 were found at the interior location of spike glycoprotein monomer but motifs 8, 9 and 10 were found at the surface of the structure, which could be used as the immunological targets for the proper diagnosis and treatment of COVID 19. The important issue of epitope . CC-BY-ND 4.0 International license author/funder. It is made available under a The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.02.021725 doi: bioRxiv preprint finalization could be confronted by the factor of possible transition between pre-fusion and postfusion spike structural distortion. Specific mutant structure has been designed and tested to be resistant to conformational change after ACE2 binding and protease cleavage at the S1/S2 site [34] . This may be indicative to searching suitable epitope which may remain unhindered from pre-to post-fusion state transition.

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