Author: Xie, Xuping; Zou, Jing; Fontes-Garfias, Camila R.; Xia, Hongjie; Swanson, Kena A.; Cutler, Mark; Cooper, David; Menachery, Vineet D.; Weaver, Scott; Dormitzer, Philip R.; Shi, Pei-Yong
Title: Neutralization of N501Y mutant SARS-CoV-2 by BNT162b2 vaccine-elicited sera Cord-id: 35vfjer8 Document date: 2021_1_7
ID: 35vfjer8
Snippet: Rapidly spreading variants of SARS-CoV-2 that have arisen in the United Kingdom and South Africa share the spike N501Y substitution, which is of particular concern because it is located in the viral receptor binding site for cell entry and increases binding to the receptor (angiotensin converting enzyme 2). We generated isogenic N501 and Y501 SARS-CoV-2. Sera of 20 participants in a previously reported trial of the mRNA-based COVID-19 vaccine BNT162b2 had equivalent neutralizing titers to the N5
Document: Rapidly spreading variants of SARS-CoV-2 that have arisen in the United Kingdom and South Africa share the spike N501Y substitution, which is of particular concern because it is located in the viral receptor binding site for cell entry and increases binding to the receptor (angiotensin converting enzyme 2). We generated isogenic N501 and Y501 SARS-CoV-2. Sera of 20 participants in a previously reported trial of the mRNA-based COVID-19 vaccine BNT162b2 had equivalent neutralizing titers to the N501 and Y501 viruses.
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