Selected article for: "negative PCR result and positive PCR result"
Author: Noam Shental; Shlomia Levy; Shosh Skorniakov; Vered Wuvshet; Yonat Shemer-Avni; Angel Porgador; Tomer Hertz
Title: Efficient high throughput SARS-CoV-2 testing to detect asymptomatic carriers
  • Document date: 2020_4_20
    • ID: bby9hls2_22
    Snippet: Since in P-Best samples are diluted into pools of 48 subjects, there is an inherent drop in PCR sensitivity of about 5-6 cycles (a factor of 2 5 -2 6 ), which was indeed observed experimentally and may result in false negative pools. In retrospective analysis, we found that only a single pool that included a carrier yielded a negative PCR result (out of expected 70 positive pools across four experiments). Similarly, only 1/122 of the negative poo.....
    Document: Since in P-Best samples are diluted into pools of 48 subjects, there is an inherent drop in PCR sensitivity of about 5-6 cycles (a factor of 2 5 -2 6 ), which was indeed observed experimentally and may result in false negative pools. In retrospective analysis, we found that only a single pool that included a carrier yielded a negative PCR result (out of expected 70 positive pools across four experiments). Similarly, only 1/122 of the negative pools was positively identified by the PCRbased assay. These two errors had no effect on the detection capabilities of P-BEST, which is robust to both of these types of errors.

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