Author: Kakimoto, Kazuki; Matsuura, Minoru; Fukuchi, Takumi; Hongo, Hitoshi; Kimura, Tsuguhiro; Aoyama, Nobuo; Okuda, Yorihide; Aomatsu, Kazuki; Kamata, Noriko; Yokoyama, Yoko; Mizuno, Chiemi; Inoue, Takuya; Miyazaki, Takako; Nakamura, Shiro; Higuchi, Kazuhide; Nakase, Hiroshi
Title: Exploratory Study of the Effectiveness of Granulocyte and Monocyte Adsorptive Apheresis Before Initiation of Steroids in Patients With Active Ulcerative Colitis (EXPECT Study): A Multicenter Prospective Clinical Trial Cord-id: 3qr79630 Document date: 2020_9_23
ID: 3qr79630
Snippet: BACKGROUND: Granulocyte and monocyte adsorptive apheresis (GMA) has been used for therapy of steroid-dependent/refractory ulcerative colitis (UC). The aim of this study was to investigate the effectiveness of GMA in UC patients not receiving steroids. METHODS: We conducted a single-arm, open-label, and multicenter prospective clinical trial. UC patients who had insufficient responses to 5-aminosalicylic acid received GMA twice a week for 5 weeks. RESULTS: The response rate of all patients was 58
Document: BACKGROUND: Granulocyte and monocyte adsorptive apheresis (GMA) has been used for therapy of steroid-dependent/refractory ulcerative colitis (UC). The aim of this study was to investigate the effectiveness of GMA in UC patients not receiving steroids. METHODS: We conducted a single-arm, open-label, and multicenter prospective clinical trial. UC patients who had insufficient responses to 5-aminosalicylic acid received GMA twice a week for 5 weeks. RESULTS: The response rate of all patients was 58.2% (39/67). Of the 39 patients who achieved a response, 74.4% achieved endoscopically confirmed mucosal healing. CONCLUSIONS: GMA shows effectiveness in inducing remission in UC patients not receiving steroid.
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