Author: Kadkhoda, Kamran
Title: Postâ€adenoviralâ€based COVIDâ€19 vaccines thrombosis: A proposed mechanism Cord-id: 6ha65hhw Document date: 2021_5_5
ID: 6ha65hhw
Snippet: There has been several reports of thrombosis and thrombocytopenia after vaccination with the ChAdOx1 nCoV-19 vaccine (Oxford-Astra-Zeneca) and Ad26.COV2.S vaccine (Johnson & Johnson/Janssen), a recombinant adenovirus serotype 26 vector encoding the SARS-CoV-2 spike glycoprotein [1, 2]. These cases clinically manifest as disseminated intravascular coagulation-like phenomena. Recently anti-platelet factor 4 (PF4) autoantibodies detected by enzyme-linked immunosorbent assays were deemed as the numb
Document: There has been several reports of thrombosis and thrombocytopenia after vaccination with the ChAdOx1 nCoV-19 vaccine (Oxford-Astra-Zeneca) and Ad26.COV2.S vaccine (Johnson & Johnson/Janssen), a recombinant adenovirus serotype 26 vector encoding the SARS-CoV-2 spike glycoprotein [1, 2]. These cases clinically manifest as disseminated intravascular coagulation-like phenomena. Recently anti-platelet factor 4 (PF4) autoantibodies detected by enzyme-linked immunosorbent assays were deemed as the number one culprit, but this finding has one main issue.
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