Author: Kinloch, Natalie N; Ritchie, Gordon; Brumme, Chanson J; Dong, Winnie; Dong, Weiyan; Lawson, Tanya; Jones, R Brad; Montaner, Julio S G; Leung, Victor; Romney, Marc G; Stefanovic, Aleksandra; Matic, Nancy; Lowe, Christopher F; Brumme, Zabrina L
Title: Suboptimal biological sampling as a probable cause of false-negative COVID-19 diagnostic test results Cord-id: 1mceq6v0 Document date: 2020_6_28
ID: 1mceq6v0
Snippet: False-negative SARS-CoV-2 test results can negatively impact the clinical and public health response to COVID-19. We used droplet digital PCR (ddPCR) to demonstrate that human DNA levels, a stable molecular marker of sampling quality, were significantly lower in samples from 40 confirmed or suspected COVID-19 cases that yielded negative diagnostic test results (i.e. suspected false-negative test results) compared to a representative pool of 87 specimens submitted for COVID-19 testing. Our result
Document: False-negative SARS-CoV-2 test results can negatively impact the clinical and public health response to COVID-19. We used droplet digital PCR (ddPCR) to demonstrate that human DNA levels, a stable molecular marker of sampling quality, were significantly lower in samples from 40 confirmed or suspected COVID-19 cases that yielded negative diagnostic test results (i.e. suspected false-negative test results) compared to a representative pool of 87 specimens submitted for COVID-19 testing. Our results support suboptimal biological sampling as a contributor to false-negative COVID-19 test results and underscore the importance of proper training and technique in the collection of nasopharyngeal specimens.
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