Características clínicas y factores de riesgo al ingreso de mortalidad en pacientes con insuficiencia cardíaca hospitalizados por COVID-19 en España

Salinas-Botrán, Alejandro; Sanz-Cánovas, Jaime; Pérez-Somarriba, Juncal; Pérez-Belmonte, Luis M; Cobos-Palacios, Lidia; Rubio-Rivas, Manuel; de Cossío Tejido, Santiago; Manuel Ramos-Rincón, José; Méndez-Bailón, Manuel; Gómez-Huelgas, Ricardo

Background: There are few studies on patients with heart failure (HF) hospitalized for COVID-19. Our aim is to describe the clinical characteristics of patients with HF hospitalized for COVID-19 and identify risk factors for in-hospital mortality upon admission. Methods: We conducted a retrospective, multicenter study in patients with HF hospitalized for COVID-19 in 150 Spanish hospitals (SEMI-COVID-19 Registry). A multivariate logistic regression analysis was performed to identify admission factors associated with in-hospital mortality. Results: A total of 1,718 patients were analyzed (56.5% men; median age 81.4 years). The overall case fatality rate was 47.6% (n=819). The independent risk factors at admission for in-hospital mortality were: age (adjusted odds ratio [AOR]: 1.03; 95% confidence interval [95%CI]: 1.02-1.05; p<.001); severe dependence (AOR: 1.62; 95%CI: 1.19-2.20; p=.002); tachycardia (AOR: 1.01; 95%CI: 1.00-1.01; p=.004); and high C-reactive protein (AOR: 1.004; 95%CI:1.002-1.004; p<.001), LDH (AOR: 1.001; 95%CI: 1.001-1.002; p<.001), and serum creatinine levels (AOR: 1.35; 95%CI: 1.18-1.54; p<.001). Conclusions: Patients with HF hospitalized for COVID-19 have a high in-hospital mortality rate. Some simple clinical and laboratory tests can help to identify patients with a worse prognosis.