Author: Ishay, Yuval; Kessler, Asa; Schwarts, Asaf; Ilan, Yaron
Title: Antibody response to SARSâ€Coâ€Vâ€2, diagnostic and therapeutic implications Cord-id: 1mxcssjj Document date: 2020_8_26
ID: 1mxcssjj
Snippet: The immune response against SARSâ€CoVâ€2 is comprised of both cellular and humoral arms. While current diagnostic methods are mainly based on PCR, they suffer from insensitivity. Therefore, antibodyâ€based serological tests are being developed to achieve higher sensitivity and specificity. Current efforts in treating SARSâ€CoVâ€2 infection include blocking of viral entry into the host cells, prohibiting viral replication and survival in the host cells, or reducing the exaggerated host immun
Document: The immune response against SARSâ€CoVâ€2 is comprised of both cellular and humoral arms. While current diagnostic methods are mainly based on PCR, they suffer from insensitivity. Therefore, antibodyâ€based serological tests are being developed to achieve higher sensitivity and specificity. Current efforts in treating SARSâ€CoVâ€2 infection include blocking of viral entry into the host cells, prohibiting viral replication and survival in the host cells, or reducing the exaggerated host immune response. Administration of convalescent plasma containing antiâ€viral antibodies was proposed to improve the outcome in severe cases. In this paper, we review some of the aspects associated with the development of antibodies against SARSâ€CoVâ€2 and their potential use for improved diagnosis and therapy.
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