Selected article for: "bat cov sequence and cov sequence"
Author: Xiaojun Li; Elena E. Giorgi; Manukumar Honnayakanahalli Marichann; Brian Foley; Chuan Xiao; Xiang-peng Kong; Yue Chen; Bette Korber; Feng Gao
Title: Emergence of SARS-CoV-2 through Recombination and Strong Purifying Selection
  • Document date: 2020_3_22
    • ID: 7v5aln90_18
    Snippet: The currently sampled pangolin CoVs are too divergent from SARS-CoV-2 for them to be SARS-CoV-2 progenitors, but it is noteworthy that these sequences contain an RBM that can most likely bind to human ACE2. While RaTG13 is the most closely related CoV sequence to SARS-CoV-2, it has a distinctive RBM, which is not expected to bind to human ACE2. SARS-CoV-2 has a nearly identical RBM to the one found in the pangolin CoVs from Guangdong. Thus, it is.....
    Document: The currently sampled pangolin CoVs are too divergent from SARS-CoV-2 for them to be SARS-CoV-2 progenitors, but it is noteworthy that these sequences contain an RBM that can most likely bind to human ACE2. While RaTG13 is the most closely related CoV sequence to SARS-CoV-2, it has a distinctive RBM, which is not expected to bind to human ACE2. SARS-CoV-2 has a nearly identical RBM to the one found in the pangolin CoVs from Guangdong. Thus, it is plausible that RaTG13-like bat-CoV viruses may have obtained the RBM sequence binding to human ACE2 through recombination with Pan_SL-CoV_GD-like viruses. We hypothesize that this, and/or other ancestral recombination events between viruses infecting bats and pangolins, may have had a key role in the evolution of the strain that lead to the introduction of SARS-CoV-2 into humans.

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