Selected article for: "antiviral efficacy and salvage pyrimidine biosynthesis"
Author: Qi Liu; Amita Gupta; Ayse Okesli-Armlovich; Wenjie Qiao; Curt R. Fischer; Mark Smith; Jan E. Carette; Michael C. Bassik; Chaitan Khosla
Title: Enhancing the Antiviral Efficacy of RNA-Dependent RNA Polymerase Inhibition by Combination with Modulators of Pyrimidine Metabolism
  • Document date: 2020_3_25
    • ID: 1zk64gsg_3
    Snippet: To restore the antiviral efficacy of GSK983 in the presence of extracellular uridine, we therefore sought to inhibit pyrimidine salvage. Cyclopentenyl uridine (CPU) is a carbocyclic analogue of uridine that has been shown to inhibit human UCK2 (Lim et al., 1984) . To our surprise, we learned that the antiviral activity of CPU is due to its remarkable ability to deplete intracellular pyrimidine nucleotide pools via salvage biosynthesis pathways. O.....
    Document: To restore the antiviral efficacy of GSK983 in the presence of extracellular uridine, we therefore sought to inhibit pyrimidine salvage. Cyclopentenyl uridine (CPU) is a carbocyclic analogue of uridine that has been shown to inhibit human UCK2 (Lim et al., 1984) . To our surprise, we learned that the antiviral activity of CPU is due to its remarkable ability to deplete intracellular pyrimidine nucleotide pools via salvage biosynthesis pathways. Our findings led us to redirect our search for a fundamentally new type of combination chemotherapy for RNA viruses, as described below.

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