Selected article for: "mmol ml and reaction mixture"
Author: Qi Liu; Amita Gupta; Ayse Okesli-Armlovich; Wenjie Qiao; Curt R. Fischer; Mark Smith; Jan E. Carette; Michael C. Bassik; Chaitan Khosla
Title: Enhancing the Antiviral Efficacy of RNA-Dependent RNA Polymerase Inhibition by Combination with Modulators of Pyrimidine Metabolism
  • Document date: 2020_3_25
    • ID: 1zk64gsg_63
    Snippet: To a solution of 3a (300 mg, 0.48 mmol, 1 equiv.) in THF (5 mL) was added TBAF (580 µL, 0.58 mmol, 1.2 equiv., 1 M in THF) at 0 ºC. After 2 h, the reaction mixture was quenched with 5 mL of saturated NH4OH solution and extracted with 5 ´ 5 mL EtOAc. The combined organic layers were dried over anhydrous Na2SO4, concentrated, loaded onto a 4 g SiO2 flash cartridge, and purified with a linear gradient 80-95% EtOAc in hexanes to afford the free pr.....
    Document: To a solution of 3a (300 mg, 0.48 mmol, 1 equiv.) in THF (5 mL) was added TBAF (580 µL, 0.58 mmol, 1.2 equiv., 1 M in THF) at 0 ºC. After 2 h, the reaction mixture was quenched with 5 mL of saturated NH4OH solution and extracted with 5 ´ 5 mL EtOAc. The combined organic layers were dried over anhydrous Na2SO4, concentrated, loaded onto a 4 g SiO2 flash cartridge, and purified with a linear gradient 80-95% EtOAc in hexanes to afford the free primary alcohol 5 (160 mg, 0.42 mmol, 87%) as white powder. The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi. org/10.1101 .03.24.992230 doi: bioRxiv preprint 1665 , 1443 , 1374 , 1239 , 1179 , 1239 , 1059 Hz, 1H), 1.43 (s, 3H), 1.34 (s, 3H). 13 C NMR (125 MHz, CDCl3) δ 168.8, 162.2, 152.5, 149.7, 141.6, 135.3, 131.5, 130.7, 129.3, 121.7, 113.0, 102.5, 84.3, 84.0, 69.2, 60.2, 27.3, 25.8

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