Selected article for: "flash cartridge and reduced pressure"
Author: Qi Liu; Amita Gupta; Ayse Okesli-Armlovich; Wenjie Qiao; Curt R. Fischer; Mark Smith; Jan E. Carette; Michael C. Bassik; Chaitan Khosla
Title: Enhancing the Antiviral Efficacy of RNA-Dependent RNA Polymerase Inhibition by Combination with Modulators of Pyrimidine Metabolism
  • Document date: 2020_3_25
    • ID: 1zk64gsg_80
    Snippet: Triethylamine (66 uL, 0.48mmol, 3 equiv.) and acetyl chloride (AcCl) (17 µL, 0.24 mmol, 1.5 equiv.) were sequentially added to a solution of 5 (60 mg, 0.16 mmol, 1 equiv.) in CH2Cl2 (2 mL) at 0 ºC. The reaction mixture was then warmed up to room temperature and stirred for another hour. A saturated solution of NH4Cl (2 mL) was added. The organic layer was extracted with 3 ´ 3 CH2Cl2, washed with H2O, and concentrated under reduced pressure. Th.....
    Document: Triethylamine (66 uL, 0.48mmol, 3 equiv.) and acetyl chloride (AcCl) (17 µL, 0.24 mmol, 1.5 equiv.) were sequentially added to a solution of 5 (60 mg, 0.16 mmol, 1 equiv.) in CH2Cl2 (2 mL) at 0 ºC. The reaction mixture was then warmed up to room temperature and stirred for another hour. A saturated solution of NH4Cl (2 mL) was added. The organic layer was extracted with 3 ´ 3 CH2Cl2, washed with H2O, and concentrated under reduced pressure. The crude material was purified through a 4g SiO2 flash cartridge with a linear gradient 65-95% EtOAc in hexanes to afford the intermediate 10 (56 mg, 0.13 mmol, 82%) as colorless oil.

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