Author: Cenciarelli, Sabina; Calbi, Valeria; Barzaghi, Federica; Bernardo, Maria Ester; Oltolini, Chiara; Migliavacca, Maddalena; Gallo, Vera; Tucci, Francesca; Fraschetta, Federico; Albertazzi, Elena; Fratini, Elena Sophia; Consiglieri, Giulia; Giannelli, Stefania; Dionisio, Francesca; Sartirana, Claudia; Racca, Sara; Camesasca, Chiara; Peretto, Giovanni; Daverio, Rita; Esposito, Antonio; De Cobelli, Francesco; Silvani, Paolo; Rabusin, Marco; Cara, Andrea; Trabattoni, Daria; Dispinseri, Stefania; Scarlatti, Gabriella; Piemonti, Lorenzo; Lampasona, Vito; Cicalese, Maria Pia; Aiuti, Alessandro; Ferrua, Francesca
Title: Mild SARS-CoV-2 Infection After Gene Therapy in a Child With Wiskott-Aldrich Syndrome: A Case Report Cord-id: 1dizqjvb Document date: 2020_11_24
ID: 1dizqjvb
Snippet: In this work we present the case of SARS-CoV-2 infection in a 1.5-year-old boy affected by severe Wiskott-Aldrich Syndrome with previous history of autoinflammatory disease, occurring 5 months after treatment with gene therapy. Before SARS-CoV-2 infection, the patient had obtained engraftment of gene corrected cells, resulting in WASP expression restoration and early immune reconstitution. The patient produced specific immunoglobulins to SARS-CoV-2 at high titer with neutralizing capacity and ex
Document: In this work we present the case of SARS-CoV-2 infection in a 1.5-year-old boy affected by severe Wiskott-Aldrich Syndrome with previous history of autoinflammatory disease, occurring 5 months after treatment with gene therapy. Before SARS-CoV-2 infection, the patient had obtained engraftment of gene corrected cells, resulting in WASP expression restoration and early immune reconstitution. The patient produced specific immunoglobulins to SARS-CoV-2 at high titer with neutralizing capacity and experienced a mild course of infection, with limited inflammatory complications, despite pre-gene therapy clinical phenotype.
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