Author: Danielle E. Goodman; Carla D. Pretto; Tomas A. Krepostman; Kelly E. Carnahan; Katherine R. Spindler
Title: Enhanced replication of mouse adenovirus type 1 following virus-induced degradation of protein kinase R (PKR) Document date: 2019_3_21
ID: 9utbwy5r_14
Snippet: infected lysates compared to mock lysates, this does not correlate to the 84% and 94% reduction, 175 respectively, in PKR protein levels at those time points (Fig. 2B ). In C57BL/6 primary peritoneal 176 macrophages, PKR mRNA levels in the infected lysates were 2-3 times higher than levels in 177 mock lysates at all three time points assayed (Fig. 3B) , even though PKR protein levels were 178 almost completely depleted in infected lysates at 72 h.....
Document: infected lysates compared to mock lysates, this does not correlate to the 84% and 94% reduction, 175 respectively, in PKR protein levels at those time points (Fig. 2B ). In C57BL/6 primary peritoneal 176 macrophages, PKR mRNA levels in the infected lysates were 2-3 times higher than levels in 177 mock lysates at all three time points assayed (Fig. 3B) , even though PKR protein levels were 178 almost completely depleted in infected lysates at 72 hpi (Fig. 2) . This is evidence that MAV-1 is 179 not causing PKR protein depletion by reducing PKR steady-state mRNA levels during infection. 180
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