Author: Danielle E. Goodman; Carla D. Pretto; Tomas A. Krepostman; Kelly E. Carnahan; Katherine R. Spindler
Title: Enhanced replication of mouse adenovirus type 1 following virus-induced degradation of protein kinase R (PKR) Document date: 2019_3_21
ID: 9utbwy5r_39
Snippet: Another hAd E4 protein, E4orf3, causes proteasomal degradation of transcriptional intermediary 402 factor 1ï§ (79) and general transcription factor II-I (80) in a manner independent of hAd E4orf6 403 and E1B 55K. E4orf3 has SUMO E3 ligase and E4 elongase activity and induces sumoylation of 404 general transcription factor II-I, leading to its proteasome-dependent degradation (80). MAV-1 405.....
Document: Another hAd E4 protein, E4orf3, causes proteasomal degradation of transcriptional intermediary 402 factor 1ï§ (79) and general transcription factor II-I (80) in a manner independent of hAd E4orf6 403 and E1B 55K. E4orf3 has SUMO E3 ligase and E4 elongase activity and induces sumoylation of 404 general transcription factor II-I, leading to its proteasome-dependent degradation (80). MAV-1 405
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