Selected article for: "nucleotide depletion and viral replication"
Author: Qi Liu; Amita Gupta; Ayse Okesli-Armlovich; Wenjie Qiao; Curt R. Fischer; Mark Smith; Jan E. Carette; Michael C. Bassik; Chaitan Khosla
Title: Enhancing the Antiviral Efficacy of RNA-Dependent RNA Polymerase Inhibition by Combination with Modulators of Pyrimidine Metabolism
  • Document date: 2020_3_25
    • ID: 1zk64gsg_22
    Snippet: To further demonstrate that intracellular nucleotide depletion is correlated with antiviral activity, we also tested the effects of combining GSK983 with a broad inhibitor of nucleoside transport, dipyridamole (DPY). This drug significantly suppressed intracellular nucleotide levels ( Figure S4 ) and consequently inhibited viral replication ( Figure S5 )......
    Document: To further demonstrate that intracellular nucleotide depletion is correlated with antiviral activity, we also tested the effects of combining GSK983 with a broad inhibitor of nucleoside transport, dipyridamole (DPY). This drug significantly suppressed intracellular nucleotide levels ( Figure S4 ) and consequently inhibited viral replication ( Figure S5 ).

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