Selected article for: "genome replication and main target"
Author: Poochi, Saravana Prabha; Easwaran, Murugesh; Balasubramanian, Balamuralikrishnan; Anbuselvam, Mohan; Meyyazhagan, Arun; Park, Sungkwon; Bhotla, Haripriya Kuchi; Anbuselvam, Jeeva; Arumugam, Vijaya Anand; Keshavarao, Sasikala; Kanniyappan, Gopalakrishnan Velliyur; Pappusamy, Manikantan; Kaul, Tanushri
Title: Employing bioactive compounds derived from Ipomoea obscura (L.) to evaluate potential inhibitor for SARS‐CoV‐2 main protease and ACE2 protein
  • Cord-id: 4ad8ubrt
  • Document date: 2020_7_6
    • ID: 4ad8ubrt
    Snippet: Angiotensin converting enzyme 2 (ACE2) and main protease (M(Pro)) are significant target proteins, mainly involved in the attachment of viral genome to host cells and aid in replication of severe acute respiratory syndrome‐coronaviruses or SARS‐CoV genome. In the present study, we identified 11 potent bioactive compounds from ethanolic leaf extract of Ipomoea obscura (L.) by using GC‐MS analysis. These potential bioactive compounds were considered for molecular docking studies against ACE2
    Document: Angiotensin converting enzyme 2 (ACE2) and main protease (M(Pro)) are significant target proteins, mainly involved in the attachment of viral genome to host cells and aid in replication of severe acute respiratory syndrome‐coronaviruses or SARS‐CoV genome. In the present study, we identified 11 potent bioactive compounds from ethanolic leaf extract of Ipomoea obscura (L.) by using GC‐MS analysis. These potential bioactive compounds were considered for molecular docking studies against ACE2 and M(Pro) target proteins to determine the antiviral effects against SARS‐COV. Results exhibits that among 11 compounds from I. obscura (L.), urso‐deoxycholic acid, demeclocycline, tetracycline, chlorotetracycline, and ethyl iso‐allocholate had potential viral inhibitory activity. Hence, the present findings suggested that chemical constitution present in I. obscura (L.) will address inhibition of corona viral replication in host cells.

    Search related documents:
    Co phrase search for related documents
    • accessible solvent area and active site: 1
    • accessible solvent area and acute respiratory infection: 1
    • accessible solvent area and acute respiratory syndrome: 1, 2, 3, 4, 5, 6, 7
    • accessory protein and active site: 1, 2
    • accessory protein and acute respiratory infection: 1, 2, 3
    • accessory protein and acute respiratory syndrome: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • active site and acute respiratory infection: 1, 2, 3, 4, 5, 6
    • active site and acute respiratory syndrome: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • active site and adme excretion: 1, 2, 3
    • active site and adme excretion metabolism: 1, 2, 3
    • active site and adme excretion metabolism distribution: 1, 2, 3
    • active site and adme excretion metabolism distribution absorption: 1, 2, 3
    • active site and adme property: 1
    • active site and liver injury: 1
    • acute kidney injury and adequate quality: 1
    • acute kidney injury and liver injury: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • acute liver injury and liver injury: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • acute respiratory infection and adequate quality: 1, 2, 3
    • acute respiratory infection and liver injury: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25