Author: Torabi, Abolfazl; Mohammadbagheri, Esmaeil; Akbari Dilmaghani, Nader; Bayat, Amir-Hossein; Fathi, Mobina; Vakili, Kimia; Alizadeh, Rafieh; Rezaeimirghaed, Omidvar; Hajiesmaeili, Mohammadreza; Ramezani, Mahtab; Simani, Leila; Aliaghaei, Abbas
Title: Proinflammatory Cytokines in the Olfactory Mucosa Result in COVID-19 Induced Anosmia Cord-id: 3bvq53i7 Document date: 2020_6_11
ID: 3bvq53i7
Snippet: [Image: see text] Studies have found increased rates of dysosmia in patients with Novel Coronavirus disease 2019 (COVID-19). However, the mechanism that causes olfactory loss is unknown. The primary objective of this study was to explore local proinflammatory cytokine levels in the olfactory epithelium in patients with COVID-19. Biopsies of the olfactory epithelium were taken from patients with confirmed COVID-19 as well as uninfected controls. Levels of tumor necrosis factor α (TNF-α) and int
Document: [Image: see text] Studies have found increased rates of dysosmia in patients with Novel Coronavirus disease 2019 (COVID-19). However, the mechanism that causes olfactory loss is unknown. The primary objective of this study was to explore local proinflammatory cytokine levels in the olfactory epithelium in patients with COVID-19. Biopsies of the olfactory epithelium were taken from patients with confirmed COVID-19 as well as uninfected controls. Levels of tumor necrosis factor α (TNF-α) and interleukin-1-beta (IL-1β) were assessed using ELISA and compared between groups. Average TNF-α levels were significantly increased in the olfactory epithelium of the COVID-19 group compared to the control group (P < 0.05). However, no differences in IL-1β were seen between groups. Elevated levels of the proinflammatory cytokine TNF-α were seen in the olfactory epithelium in patients with COVID-19. This suggests that direct inflammation of the olfactory epithelium could play a role in the acute olfactory loss described in many patients with COVID-19.
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