Author: Cohen-Dvashi, Hadas; Weinstein, Jonathan; Katz, Michael; Eilon, Maayan; Mor, Yuval; Shimon, Amir; Strobelt, Romano; Shemesh, Maya; Fleishman, Sarel J; Diskin, Ron
Title: Coronacept – a potent immunoadhesin against SARS-CoV-2 Cord-id: 3vr2sv1d Document date: 2020_8_12
ID: 3vr2sv1d
Snippet: Angiotensin-converting enzyme 2 (ACE2) is the cellular receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Computational analysis of mammalian ACE2 orthologues suggests various residues at the interface with the viral receptor binding domain that could facilitate tighter interaction compared to the human-ACE2. Introducing several mutations to the human-ACE2 resulted with significantly augmented affinity to the viral spike complex. This modified human-ACE2 fused to an Fc po
Document: Angiotensin-converting enzyme 2 (ACE2) is the cellular receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Computational analysis of mammalian ACE2 orthologues suggests various residues at the interface with the viral receptor binding domain that could facilitate tighter interaction compared to the human-ACE2. Introducing several mutations to the human-ACE2 resulted with significantly augmented affinity to the viral spike complex. This modified human-ACE2 fused to an Fc portion of an antibody makes a potent immunoadhesin that effectively targets SARS-CoV-2.
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