Selected article for: "purifying selection and selection pressure"
Author: Xiaojun Li; Elena E. Giorgi; Manukumar Honnayakanahalli Marichann; Brian Foley; Chuan Xiao; Xiang-peng Kong; Yue Chen; Bette Korber; Feng Gao
Title: Emergence of SARS-CoV-2 through Recombination and Strong Purifying Selection
  • Document date: 2020_3_22
    • ID: 7v5aln90_19
    Snippet: All three human CoVs (SARS, MERS and SARS-2) are the result of recombination among CoVs. Recombination in all three viruses involved the S gene, likely a precondition to zoonosis that enabled efficient binding to human receptors (5, 17) . Extensive recombination among bat coronaviruses and strong purifying selection pressure among viruses from humans, bats and pangolin may allow such closely related viruses ready jump between species and adapt to.....
    Document: All three human CoVs (SARS, MERS and SARS-2) are the result of recombination among CoVs. Recombination in all three viruses involved the S gene, likely a precondition to zoonosis that enabled efficient binding to human receptors (5, 17) . Extensive recombination among bat coronaviruses and strong purifying selection pressure among viruses from humans, bats and pangolin may allow such closely related viruses ready jump between species and adapt to the new hosts. Many bat CoVs have been found able to bind to human ACE2 and replication in human cells (10, 19, (31) (32) (33) . Serological evidence has revealed that additional otherwise undetected spillovers have occurred in people in China living in proximity to wild bat populations (34) . Continuous surveillance of coronaviruses in their natural hosts and in humans will be key to rapid control of new coronavirus outbreaks.

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