Author: Laura Riva; Shuofeng Yuan; Xin Yin; Laura Martin-Sancho; Naoko Matsunaga; Sebastian Burgstaller-Muehlbacher; Lars Pache; Paul P. De Jesus; Mitchell V. Hull; Max Chang; Jasper Fuk-Woo Chan; Jianli Cao; Vincent Kwok-Man Poon; Kristina Herbert; Tu-Trinh Nguyen; Yuan Pu; Courtney Nguyen; Andrey Rubanov; Luis Martinez-Sobrido; Wen-Chun Liu; Lisa Miorin; Kris M. White; Jeffrey R. Johnson; Christopher Benner; Ren Sun; Peter G. Schultz; Andrew Su; Adolfo Garcia-Sastre; Arnab K. Chatterjee; Kwok-Yung Yuen; Sumit K. Chanda
Title: A Large-scale Drug Repositioning Survey for SARS-CoV-2 Antivirals Document date: 2020_4_17
ID: 1fgnfh62_70
Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.16.044016 doi: bioRxiv preprint the biology of this coronavirus, and to guide additional directed repurposing studies, particularly of existing late-stage preclinical assets. Critically, this campaign led to the identification and validation of 30 molecules with antiviral activities against SARS-CoV-2, including four FDA-approved compound.....
Document: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.16.044016 doi: bioRxiv preprint the biology of this coronavirus, and to guide additional directed repurposing studies, particularly of existing late-stage preclinical assets. Critically, this campaign led to the identification and validation of 30 molecules with antiviral activities against SARS-CoV-2, including four FDA-approved compounds, one drug registered in Japan, and 11 molecules that have entered clinical trials. The availability of human safety and pharmacological data of these molecules is expected to enable rapid preclinical and clinical assessment of these compounds. However, expedited regulatory review under EUA guidelines also provides a rationale for the development of earlier stage candidate molecules that can be deployed for use during this current pandemic outbreak. It is critical that multiple therapeutic options that demonstrate efficacy against SARS-CoV-2 are available to mitigate potential emergence of drug resistance, as well as enable the evaluation of optimal therapeutic cocktails that are broadly curative for COVID-19 disease.
Search related documents:
Co phrase search for related documents- antiviral activity and current pandemic outbreak: 1
- antiviral activity and drug resistance: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33
- antiviral activity and drug resistance potential emergence: 1
- antiviral activity and human safety: 1, 2, 3, 4, 5, 6, 7, 8
- antiviral activity and late stage: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
- antiviral activity and pandemic outbreak: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20
- antiviral activity and potential emergence: 1, 2, 3, 4, 5, 6, 7, 8, 9
- antiviral activity and repurpose study: 1
- antiviral activity and SARS antiviral activity: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78
- antiviral activity and SARS efficacy: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42
- antiviral activity and therapeutic cocktail: 1
- antiviral activity and therapeutic option: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
- clinical preclinical assessment and human safety: 1
- clinical trial and drug resistance: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13
- clinical trial and FDA approve: 1
- clinical trial and human safety: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21
- clinical trial and Japan register: 1
- clinical trial and late stage: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
- clinical trial and pandemic outbreak: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16
Co phrase search for related documents, hyperlinks ordered by date