Author: Qi Liu; Amita Gupta; Ayse Okesli-Armlovich; Wenjie Qiao; Curt R. Fischer; Mark Smith; Jan E. Carette; Michael C. Bassik; Chaitan Khosla
Title: Enhancing the Antiviral Efficacy of RNA-Dependent RNA Polymerase Inhibition by Combination with Modulators of Pyrimidine Metabolism Document date: 2020_3_25
ID: 1zk64gsg_74
Snippet: To the mesylate intermediate 8 (26 mg, 0.056 mmol, 1 equiv.) was added DMF (3 mL) and NaN3 (80 mg, 1.23 mmol, 22 equiv.). The resulting suspension was heated to 100°C and stirred for 18 hours, followed by the addition of 3 mL saturated solution of NH4Cl. The organic layer was extracted with 3 ´ 5 Et2O, washed with brine, and concentrated under reduced pressure. The crude material was purified through a 4g SiO2 flash cartridge with a linear grad.....
Document: To the mesylate intermediate 8 (26 mg, 0.056 mmol, 1 equiv.) was added DMF (3 mL) and NaN3 (80 mg, 1.23 mmol, 22 equiv.). The resulting suspension was heated to 100°C and stirred for 18 hours, followed by the addition of 3 mL saturated solution of NH4Cl. The organic layer was extracted with 3 ´ 5 Et2O, washed with brine, and concentrated under reduced pressure. The crude material was purified through a 4g SiO2 flash cartridge with a linear gradient 40-95% EtOAc in hexanes to afford the azide intermediate S2 (14 mg, 0.046 mmol, 82%) as brown oil.
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