Selected article for: "adaptive immune response and immune system"

Author: Luzi, Livio; Radaelli, Maria Grazia
Title: Influenza and obesity: its odd relationship and the lessons for COVID-19 pandemic
  • Cord-id: 7cmyfxu9
  • Document date: 2020_4_5
  • ID: 7cmyfxu9
    Snippet: AIMS: Analyze the relationship between obesity and influenza. METHODS: Basal hormone milieu, defective response of both innate and adaptive immune system and sedentariness are major determinants in the severity of influenza viral infection in obese patients. Being overweight not only increases the risk of infection and of complications for the single obese person, but a large prevalence of obese individuals within the population might increase the chance of appearance of more virulent viral stra
    Document: AIMS: Analyze the relationship between obesity and influenza. METHODS: Basal hormone milieu, defective response of both innate and adaptive immune system and sedentariness are major determinants in the severity of influenza viral infection in obese patients. Being overweight not only increases the risk of infection and of complications for the single obese person, but a large prevalence of obese individuals within the population might increase the chance of appearance of more virulent viral strain, prolongs the virus shedding throughout the total population and eventually might increase overall mortality rate of an influenza pandemic. RESULTS: Waiting for the development of a vaccination against COVID-19, isolation of positive cases and social distancing are the primary interventions. Nonetheless, evidence from previous influenza pandemics suggests the following interventions aimed at improving immune response: (1) lose weight with a mild caloric restriction; (2) include AMPK activators and PPAR gamma activators in the drug treatment for obesity associated with diabetes; and (3) practice mild-to-moderate physical exercise. CONCLUSIONS: Due to prolonged viral shedding, quarantine in obese subjects should likely be longer than normal weight individuals.

    Search related documents:
    Co phrase search for related documents
    • activation inflammatory effect and lung injury: 1
    • activity increase and adaptive immune response: 1
    • activity increase and adaptive immune system: 1
    • activity increase and adolescent child: 1, 2, 3
    • activity increase and low grade chronic: 1
    • activity increase and low grade chronic inflammation: 1
    • activity increase and lung injury: 1, 2, 3, 4, 5, 6, 7, 8
    • activity increase and lung liver: 1, 2, 3
    • activity increase and lung liver heart: 1
    • activity increase and macrophage activation: 1, 2
    • activity increase and macrophage chemoattractant protein: 1
    • activity increase and macrophage monocyte: 1, 2
    • adaptive cellular and low grade chronic: 1
    • adaptive cellular and macrophage activation: 1
    • adaptive immune response and low grade chronic: 1
    • adaptive immune response and low grade chronic inflammation: 1
    • adaptive immune response and low grade chronic inflammation state: 1
    • adaptive immune response and lung injury: 1, 2, 3, 4, 5, 6, 7, 8, 9
    • adaptive immune response and lung liver: 1, 2, 3