Epidemiological and clinical features of 2019-nCoV acute respiratory disease cases in Chongqing municipality, China: a retrospective, descriptive, multiple-center study

Di Qi; Xiaofeng Yan; Xumao Tang; Junnan Peng; Qian Yu; Longhua Feng; Guodan Yuan; An Zhang; Yaokai Chen; Jing Yuan; Xia Huang; Xianxiang Zhang; Peng Hu; Yuyan Song; Chunfang Qian; Qiangzhong Sun; Daoxin Wang; Jin Tong; Jianglin Xiang

The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.03.01.20029397 doi: medRxiv preprint proinflammatory Th17 and cytotoxic CD8 T cells, partially accounts for the severe immune injury in death patient 26 . The phenomenon that T cell counts reduced and functionally exhausted has been reported in previous study, which indicates high risk for further deterioration of COVID-19 27 . In our study, a progressive decline of lymphocytes and CD4 positive T cells was observed during the deterioration of illness. presented as elevated levels of infectious parameters, but other abnormalities were less common. While, severe patients obviously manifested more prominent abnormalities, suggesting multiple organ dysfunction and poor outcomes. Additionally, severe cases suffered from lower albumin and hemoglobin, suggesting the importance of nutrition supportive treatments. As for radiologic presentations, more attention should be paid to the cases without obvious radiological abnormalities on admission, so as to avoid the miss or delayed diagnosis. Therefore, it is crucial important to take symptoms, laboratory findings, radiologic findings into account to make an integrated and thorough judgment. The MuLBSTA score, an efficient early warning model for predicting mortality in viral pneumonia 30 , needs further validation in the future practice.