Epidemiology, clinical course, and outcomes of critically ill adults with COVID-19 in New York City: a prospective cohort study

Matthew J Cummings; Matthew R Baldwin; Darryl Abrams; Samuel D Jacobson; Benjamin J Meyer; Elizabeth M Balough; Justin G Aaron; Jan Claassen; LeRoy E Rabbani; Jonathan Hastie; Beth R Hochman; John Salazar-Schicchi; Natalie H Yip; Daniel Brodie; Max R O'Donnell

Second, our analyses incorporated data collected through April 14 th , 2020. As definitive inhospital vital status is not yet known for patients who remained hospitalized after this date, the 33% of inpatient deaths reported here represent the minimum in-hospital case-fatality-rate for our cohort. Third, patients presented to the hospital at varying times in their illness course, which may have impacted their clinical course and outcomes. To mitigate the potential impact of this variance on our analyses, we included time from symptom onset to presentation as a covariable in our regression models. Fourth, of available biomarkers, we included IL-6 and d-dimer in our multivariable models given pathophysiologic and treatment implications. We did not All rights reserved. No reuse allowed without permission. author/funder, who has granted medRxiv a license to display the preprint in perpetuity.