Author: Wrobel, Antoni G.; Benton, Donald J.; Hussain, Saira; Harvey, Ruth; Martin, Stephen R.; Roustan, Chloë; Rosenthal, Peter B.; Skehel, John J.; Gamblin, Steven J.
Title: Antibody-mediated disruption of the SARS-CoV-2 spike glycoprotein Cord-id: cv2my57c Document date: 2020_10_21
ID: cv2my57c
Snippet: The CR3022 antibody, selected from a group of SARS-CoV monoclonal antibodies for its ability to cross-react with SARS-CoV-2, has been examined for its ability to bind to the ectodomain of the SARS-CoV-2 spike glycoprotein. Using cryo-electron microscopy we show that antibody binding requires rearrangements in the S1 domain that result in dissociation of the spike.
Document: The CR3022 antibody, selected from a group of SARS-CoV monoclonal antibodies for its ability to cross-react with SARS-CoV-2, has been examined for its ability to bind to the ectodomain of the SARS-CoV-2 spike glycoprotein. Using cryo-electron microscopy we show that antibody binding requires rearrangements in the S1 domain that result in dissociation of the spike.
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