Natural occurrence of products of cryptic pathway metabolites of pharmacological importance using liquid chromatographic-mass spectrometric techniques in date palm fruit, garlic bulb and groundnuts from North-West Nigeria markets

Adeniran, L. A.; Anjorin, T. S.; Sulyok, M.; Krska, R.; Ajagbonna, O. P.; Department of Veterinary, Physiology Biochemistry Faculty of Veterinary Medicine University of Abuja Abuja Nigeria

Investigation of secondary metabolites from the cryptic metabolic pathways in date palm fruit, garlic bulb and groundnuts from North-West Nigeria was conducted using liquid chromatography-mass spectrometry and mass spectrometry (LC-MS/MS). Results indicated the presence of several compounds which include Valinomycin, asperglaucide, asperphenamate, cyclo (L-Pro-L-Tyr). Cyclo (L-Pro-L-Val), emodin, physcion, integracin A and B, Monocerin, and fallacinol were detected at different concentrations in the different sampled materials. Asperglaucide, asperphenamate, cyclo (L-Pro-L-Tyr), cyclo (L-Pro-L-Val), and emodin were found in all the tested samples at different concentrations. Garlic bulb contains valinomycin, emodin and physcion which are compoundthat may have a potential inhibitory effect on severe acute respiratory syndrome coronavirus (SARS-CoV) with their maximum concentration of 55.15, 20.25 and 419.45 micro g/kg respectively in the tested materials. Integracin A and B which are compound with potential inhibitory effect on the HIV-1 integrase enzyme found in Human immune deficiency virus (HIV) were detected in garlic bulb samples at the maximum concentration of (3.98 and 18.68 micro g/kg) respectively. This study has identified the presence of a compound of immense pharmacological importance, and it may provide a veritable lead for natural product discovery.