Selected article for: "maximum score and minimum score"
Author: M. Shaminur Rahman; M. Nazmul Hoque; M. Rafiul Islam; Salma Akter; A. S. M. Rubayet-Ul-Alam; Mohammad Anwar Siddique; Otun Saha; Md. Mizanur Rahaman; Munawar Sultana; M. Anwar Hossain
Title: Epitope-based chimeric peptide vaccine design against S, M and E proteins of SARS-CoV-2 etiologic agent of global pandemic COVID-19: an in silico approach
  • Document date: 2020_3_31
    • ID: 0yqyclxk_4
    Snippet: were not selected as the potential epitope candidate because of their presence in viral 172 transmembrane domains ( Supplementary Fig. 3) . The tertiary structures of the RBD and NTD 173 illustrate their surface-exposed position on the S protein (Fig. 2) . 174 protein possessed only one highly antigenic epitope (57- 194 antigenicity score = 0.449) which might be potentially functional in host cell binding (Table 2) . 195 Furthermore, the Kolaskar.....
    Document: were not selected as the potential epitope candidate because of their presence in viral 172 transmembrane domains ( Supplementary Fig. 3) . The tertiary structures of the RBD and NTD 173 illustrate their surface-exposed position on the S protein (Fig. 2) . 174 protein possessed only one highly antigenic epitope (57- 194 antigenicity score = 0.449) which might be potentially functional in host cell binding (Table 2) . 195 Furthermore, the Kolaskar and Tongaonkar antigenicity profiling found five highly antigenic 196 epitopes in RBD region with an average (antigenicity) score of 1.042 (minimum = 0.907, 197 maximum = 1.214), and seven highly antigenic epitopes in NTD with an average (antigenicity) 198 score of 1.023 (minimum = 0.866, maximum = 1.213) ( Supplementary Fig. 4 , Supplementary 199 Table 2 ). The average Kolaskar scores for envelop protein B-cell epitope (EBE) and membrane 200 protein B-cell epitope (MBE) were 0.980 and 1.032, respectively (Supplementary Table 2) . 201

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