In vivo gene delivery mediated by non-viral vectors for cancer therapy

Mohammadinejad, Reza; Dehshahri, Ali; Madamsetty, Vijay Sagar; Zahmatkeshan, Masoumeh; Tavakol, Shima; Makvandi, Pooyan; Khorsandi, Danial; Pardakhty, Abbas; Ashrafizadeh, Milad; Afshar, Elham Ghasemipour; Zarrabi, Ali

Gene therapy by expression constructs or down-regulation of certain genes has shown great potential for the treatment of various diseases. The wide clinical application of nucleic acid materials dependents on the development of biocompatible gene carriers. There are enormous various compounds widely investigated to be used as non-viral gene carriers including lipids, polymers, carbon materials, and inorganic structures. In this review, we will discuss the recent discoveries on non-viral gene delivery systems. We will also highlight the in vivo gene delivery mediated by non-viral vectors to treat cancer in different tissue and organs including brain, breast, lung, liver, stomach, and prostate. Finally, we will delineate the state-of-the-art and promising perspective of in vivo gene editing using non-viral nano-vectors.