Author: Breslin, Jamie J; Mørk, Irene; Smith, M K; Vogel, Lotte K; Hemmila, Erin M; Bonavia, Aurelio; Talbot, Pierre J; Sjöström, Hans; Norén, Ove; Holmes, Kathryn V
Title: Human coronavirus 229E: receptor binding domain and neutralization by soluble receptor at 37 degrees C. Cord-id: d66j0330 Document date: 2003_1_1
ID: d66j0330
Snippet: Truncated human coronavirus HCoV-229E spike glycoproteins containing amino acids 407 to 547 bound to purified, soluble virus receptor, human aminopeptidase N (hAPN). Soluble hAPN neutralized the infectivity of HCoV-229E virions at 37 degrees C, but not 4 degrees C. Binding of hAPN may therefore trigger conformational changes in the viral spike protein at 37 degrees C that facilitate virus entry.
Document: Truncated human coronavirus HCoV-229E spike glycoproteins containing amino acids 407 to 547 bound to purified, soluble virus receptor, human aminopeptidase N (hAPN). Soluble hAPN neutralized the infectivity of HCoV-229E virions at 37 degrees C, but not 4 degrees C. Binding of hAPN may therefore trigger conformational changes in the viral spike protein at 37 degrees C that facilitate virus entry.
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