Author: Yasuhiko Kamikubo; Atsushi Takahashi
Title: Epidemiological Tools that Predict Partial Herd Immunity to SARS Coronavirus 2 Document date: 2020_3_27
ID: 7onenxg7_7
Snippet: A population genetic study of 103 SARS-CoV-2 genomes has identified two viral subtypes designate S and L. 5 The S type is the ancestral version of the virus. Notably, only 1 out of 27 (3.7%) viral strains isolated from Wuhan was S type, while 10 out of 31 (32.3%) from other places in China and 18 out of 45 (40.0%) outside the country were S type. The L type has accumulated more mutations than the S type and the orf1ab replicase/transcriptase gene.....
Document: A population genetic study of 103 SARS-CoV-2 genomes has identified two viral subtypes designate S and L. 5 The S type is the ancestral version of the virus. Notably, only 1 out of 27 (3.7%) viral strains isolated from Wuhan was S type, while 10 out of 31 (32.3%) from other places in China and 18 out of 45 (40.0%) outside the country were S type. The L type has accumulated more mutations than the S type and the orf1ab replicase/transcriptase gene of L type has a codon that is more preferred for translation than S type, suggesting that the L type replicates and/or transmits faster than the S type.
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