Selected article for: "genetic diversity and SARS cov pathogenesis"
Author: Mohammadi, Elmira; Shafiee, Fatemeh; Shahzamani, Kiana; Ranjbar, Mohammad Mehdi; Alibakhshi, Abbas; Ahangarzadeh, Shahrzad; Beikmohammadi, Leila; Shariati, Laleh; Hooshmandi, Soodeh; Ataei, Behrooz; Javanmard, Shaghayegh Haghjooy
Title: Novel and emerging mutations of SARS-CoV-2: Biomedical implications
  • Cord-id: rlw166s1
  • Document date: 2021_4_23
    • ID: rlw166s1
    Snippet: Coronavirus disease-19 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The SARS-CoV-2 virus strains has geographical diversity associated with diverse severity, mortality rate, and response to treatment that were characterized using phylogenetic network analysis of SARS-CoV-2 genomes. Although, there is no explicit and integrative explanation for these variations, the genetic arrangement, and stability of SARS-CoV-2 are basic contributing factors to its viru
    Document: Coronavirus disease-19 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The SARS-CoV-2 virus strains has geographical diversity associated with diverse severity, mortality rate, and response to treatment that were characterized using phylogenetic network analysis of SARS-CoV-2 genomes. Although, there is no explicit and integrative explanation for these variations, the genetic arrangement, and stability of SARS-CoV-2 are basic contributing factors to its virulence and pathogenesis. Hence, understanding these features can be used to predict the future transmission dynamics of SARS-CoV-2 infection, drug development, and vaccine. In this review, we discuss the most recent findings on the mutations in the SARS-CoV-2, which provide valuable information on the genetic diversity of SARS-CoV-2, especially for DNA-based diagnosis, antivirals, and vaccine development for COVID-19.

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