Author: Kim, Gil Soo; Kim, Geum Jin; Lee, Byeongsan; Oh, Tae Hoon; Kwon, Mincheol; Lee, Jung-Sook; Jang, Jun-Pil; Choi, Hyukjae; Ko, Sung-Kyun; Hong, Young-Soo; Jang, Jae-Hyuk; Ahn, Jong Seog
Title: Highly oxygenated angucycline from Streptomyces sp. KCB15JA014. Cord-id: d8mgotb1 Document date: 2020_7_10
ID: d8mgotb1
Snippet: LC/MS-based chemical screening of culture extract led to a new highly oxygenated angucycline derivative, grecocycline D (1), from Streptomyces sp. KCB15JA014, isolated from a soil sample of Oedolgae in Jeju Island, Korea. The planar structure was determined on the basis of spectroscopic analysis, including 1D and 2D NMR techniques as well as HRESIMS and comparison with data from the literature. A relative and absolute configuration of 1 was assigned by ROESY experiment and electronic circular di
Document: LC/MS-based chemical screening of culture extract led to a new highly oxygenated angucycline derivative, grecocycline D (1), from Streptomyces sp. KCB15JA014, isolated from a soil sample of Oedolgae in Jeju Island, Korea. The planar structure was determined on the basis of spectroscopic analysis, including 1D and 2D NMR techniques as well as HRESIMS and comparison with data from the literature. A relative and absolute configuration of 1 was assigned by ROESY experiment and electronic circular dichroism calculation. Compound 1 showed weak inhibitory activity against indoleamine 2,3-dioxygenase.
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