Selected article for: "activity study and low activity"
Author: Tabatabai, Ali; Rabin, Joseph; Menaker, Jay; Madathil, Ronson; Galvagno, Samuel; Menne, Ashley; Chow, Jonathan H.; Grazioli, Alison; Herr,, Daniel; Tanaka, Kenichi; Scalea, Thomas; Mazzeffi, Michael
Title: Factor VIII and Functional Protein C Activity in Critically Ill Patients With Coronavirus Disease 2019: A Case Series
  • Cord-id: d9vtjy46
  • Document date: 2020_5_11
    • ID: d9vtjy46
    Snippet: Critically ill patients with coronavirus disease 2019 (COVID-19) have been observed to be hypercoagulable, but the mechanisms for this remain poorly described. Factor VIII is a procoagulant factor that increases during inflammation and is cleaved by activated protein C. To our knowledge, there is only 1 prior study of factor VIII and functional protein C activity in critically ill patients with COVID-19. Here, we present a case series of 10 critically ill patients with COVID-19 who had severe el
    Document: Critically ill patients with coronavirus disease 2019 (COVID-19) have been observed to be hypercoagulable, but the mechanisms for this remain poorly described. Factor VIII is a procoagulant factor that increases during inflammation and is cleaved by activated protein C. To our knowledge, there is only 1 prior study of factor VIII and functional protein C activity in critically ill patients with COVID-19. Here, we present a case series of 10 critically ill patients with COVID-19 who had severe elevations in factor VIII activity and low normal functional protein C activity, which may have contributed to hypercoagulability.

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