Selected article for: "high morbidity and SARS outbreak"
Author: Jia, Zhilong; Song, Xinyu; Shi, Jinlong; Wang, Weidong; He, Kunlun
Title: Transcriptome-based drug repositioning for coronavirus disease 2019 (COVID-19)
  • Cord-id: 7rnhqodj
  • Document date: 2020_7_15
    • ID: 7rnhqodj
    Snippet: The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) around the world has led to a pandemic with high morbidity and mortality. However, there are no effective drugs to prevent and treat the disease. Transcriptome-based drug repositioning, identifying new indications for old drugs, is a powerful tool for drug development. Using bronchoalveolar lavage fluid transcriptome data of COVID-19 patients, we found that the endocytosis and lysosome pathways are highly involved in th
    Document: The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) around the world has led to a pandemic with high morbidity and mortality. However, there are no effective drugs to prevent and treat the disease. Transcriptome-based drug repositioning, identifying new indications for old drugs, is a powerful tool for drug development. Using bronchoalveolar lavage fluid transcriptome data of COVID-19 patients, we found that the endocytosis and lysosome pathways are highly involved in the disease and that the regulation of genes involved in neutrophil degranulation was disrupted, suggesting an intense battle between SARS-CoV-2 and humans. Furthermore, we implemented a coexpression drug repositioning analysis, cogena, and identified two antiviral drugs (saquinavir and ribavirin) and several other candidate drugs (such as dinoprost, dipivefrine, dexamethasone and (-)-isoprenaline). Notably, the two antiviral drugs have also previously been identified using molecular docking methods, and ribavirin is a recommended drug in the diagnosis and treatment protocol for COVID pneumonia (trial version 5–7) published by the National Health Commission of the P.R. of China. Our study demonstrates the value of the cogena-based drug repositioning method for emerging infectious diseases, improves our understanding of SARS-CoV-2-induced disease, and provides potential drugs for the prevention and treatment of COVID-19 pneumonia.

    Search related documents:
    Co phrase search for related documents
    • accessory structural and lung injury: 1
    • action drug mechanism and acute ards respiratory distress syndrome: 1
    • action drug mechanism and lung disease: 1
    • action drug mechanism and lung injury: 1
    • acute ards respiratory distress syndrome ali and low respiratory tract: 1
    • acute ards respiratory distress syndrome ali and low upper respiratory: 1
    • acute ards respiratory distress syndrome ali and low upper respiratory tract: 1
    • acute ards respiratory distress syndrome ali and lung disease: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13
    • acute ards respiratory distress syndrome ali and lung injury: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • acute ards respiratory distress syndrome and low express: 1
    • acute ards respiratory distress syndrome and low respiratory tract: 1, 2
    • acute ards respiratory distress syndrome and low upper respiratory: 1
    • acute ards respiratory distress syndrome and low upper respiratory tract: 1
    • acute ards respiratory distress syndrome and lung disease: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • acute ards respiratory distress syndrome and lung injury: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • acute sars cov respiratory syndrome cov and low upper respiratory: 1
    • acute sars cov respiratory syndrome cov and low upper respiratory tract: 1
    • acute sars cov respiratory syndrome cov and lung disease: 1, 2, 3, 4, 5, 6, 7, 8
    • acute sars cov respiratory syndrome cov and lung injury: 1, 2, 3