Epidemiological, Clinical Characteristics and Outcome of Medical Staff Infected with COVID-19 in Wuhan, China: A Retrospective Case Series Analysis

Jie Liu; Liu Ouyang; Pi Guo; Hai sheng Wu; Peng Fu; Yu liang Chen; Dan Yang; Xiao yu Han; Yu kun Cao; Osamah Alwalid; Juan Tao; Shu yi Peng; He shui Shi; Fan Yang; Chuan sheng Zheng

examinations and radiological studies. These included age, sex, occupation (doctor, or nurse), body mass index (BMI ≥ 24, or <24 kg/m 2 ), current smoking status (yes, or no), disease severity (non-severe, or severe), date of symptom onset, symptoms before hospital admission (fever, cough, fatigue, sore throat, myalgia, sputum production, difficulty breathing or chest tightness, chill, loss of appetite, diarrhea, and chest pain), coexisting conditions (e.g. hypertension, diabetes, etc.), laboratory testing indicators on admission (leucocyte count, lymphocyte count, platelet count, D-dimer, creatinine, creatine kinase, lactose dehydrogenase, alanine aminotransferase, aspartate aminotransferase, hemoglobin, ferritin, C-reactive protein, Amyloid A, total bilirubin, procalcitonin, erythrocyte sedimentation rate, interleukin-6 (IL-6) and lymphocyte subsets, etc.), radiologic assessments of chest CT (lung involvement, lung lobe involvement, predominant CT changes, predominant distribution of opacities, etc.), treatment measures (antibiotics agents, antiviral agents, traditional Chinese medicine, immune globulin, thymosin, corticosteroids and oxygen therapy), and complications (e.g. pneumonia, acute respiratory distress syndrome, acute cardiac injury, acute kidney injury, shock, etc.). All CT images were analyzed by two radiologists (J.L. and F.Y., who had 5 and 21 years of experience in thoracic radiology, respectively) utilizing the institutional digital database system without access to clinical and laboratory findings. Images were reviewed independently, and final decisions were reached by discussion and consensus. We estimated the time interval from symptom onset to admission with maximum information available -that is, all the exact date of initial symptoms provided by the patients. Then the aggregated data was sent to data analysis group. Prior to statistical analysis, the aggregated data were cross -checked by group members to guarantee the correctness and completeness of data.