Author: Rosendal, E.; Wigren, J.; Groening, R.; Yongdae, K.; Nilsson, E.; Sharma, A.; espaillat, a.; Hanke, L.; Thunberg, T.; McInerney, G.; Puhar, A.; Cava, F.; Karlsson Hedestam, G. B.; Monsen, T.; Elgh, F.; Blomkvist, B.; Marklund, I.; Ahlm, C.; Evander, M.; Normark, J.; Johansson, A.; Overby, A. K.; Forsell, M.
Title: Detection of asymptomatic SARS-CoV-2 exposed individuals by a sensitive S-based ELISA. Cord-id: frwte0tp Document date: 2020_6_4
ID: frwte0tp
Snippet: To assess the current coronavirus pandemic, there is a pressing need to determine the exposure and seroconversion to SARS-CoV-2 on a local and global level. Here, we demonstrate a sensitive and specific S-protein based assay that is well suited for detection of weak SARS- CoV-2-directed IgG responses, and that could identify exposed individuals with asymptomatic infection without the requirement of PCR diagnostics. Our results raise the possibility that on- going population-based studies using l
Document: To assess the current coronavirus pandemic, there is a pressing need to determine the exposure and seroconversion to SARS-CoV-2 on a local and global level. Here, we demonstrate a sensitive and specific S-protein based assay that is well suited for detection of weak SARS- CoV-2-directed IgG responses, and that could identify exposed individuals with asymptomatic infection without the requirement of PCR diagnostics. Our results raise the possibility that on- going population-based studies using less sensitive state-of-the-art serological assays may significantly underestimate the frequency of exposure and seroconversion to SARS-CoV-2.
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